Migraine
We leverage an in-depth understanding of local patient populations to drive patient recruitment campaigns for global migraine clinical trials
An ongoing challenge in migraine research is that participation in clinical trials is hindered by migraine patients not searching help because of stigma and lack of awareness as they see the disease as just a “headache”, as the US Migraine Foundation states in a recent report. As a result, some 75% of all patients remaining undiagnosed according to recent estimates published in Neurology, traditional recruitment methods or basic digital recruitment are insufficient.
Having performed migraine patient recruitment for 10+ international trials, from Phase I to IV (including both adult and adolescent patients), we know how to reach and enroll migraine patients of various backgrounds.
Migraine
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Migraine
Understanding and recruiting migraine patients of various backgrounds
Clinical trials for migraine usually focus on one of two types of the condition: migraine with aura and migraine without aura, with the latter referring to headache that happen alongside or are preceded by sensory disturbances. Yet, there are many types of migraine and more so, recent reports estimate that a large part of the global migraine patient population remains undiagnosed.
This means it is on the one hand crucial that study organizers match their study protocol with the potential study population in proximity to planned sites. On the other hand, it requires outreach methods that reach patients who fulfil the study requirements but, for various reasons from stigma to lack of awareness, do not look for alternative treatment options through for example doctor offices.
At Clariness, we leverage our thorough understanding of the local patient populations in our patient-centric digital patient recruitment campaigns for migraine. We conduct our own surveys, but have also supported the largest ever survey of 21,000 migraine patients in Germany to determine migraine patients’ needs and willingness to participate. In combination with data-driven evaluations, we can accelerate the recruitment of your migraine studies.
Migraine
Migraine patient surveys: understanding the local study populations
Any successful patient recruitment campaigns depends on a understanding of the to be recruited patient population. How do they feel about current treatment options, how aware are they about their condition, what are their perceived benefits and challenges that influences their willingness to participate?
This understanding is essential for selecting the most effective recruitment channels and which types of advertising work best for specific digital patient communities.
There are a number of ways that sponsors can improve their understanding of migraine patient populations for their planned clinical trial. At Clariness, we regularly conduct patient interviews, stay up to date with academic research on migraine patients and with our Patient Centric ClinLife portal support sponsors who want to conduct patient surveys for migraine.
We for example supported the largest migraine survey to date in Germany, which results in early 2022 were published in Nature and were summarized in our whitepaper “Patient understanding and recruitment for Migraine Trials”.
How we can help
How can Clariness support my dermatology studies?
We have several options:
1. List your study on our global patient portal, ClinLife®
2. List your study on ClinLife® and launch a tailored recruitment campaign
Interested in a strategy session to discuss how we can tailor a campaign for you?
2021 Patient’s Voice participant
Some recent successes
Case Study
Migraine case study
How we can help
Our services and solutions
Leverage our experts, data and platforms, to accelerate your clinical trials
Demographic
- Gender, age, ethnicity, social-economic class, location, and other demographics are used as filters to find patients (and their families) most likely to match the study.
Location
- We reach patients living in an area with a high prevalence of diabetes (and related causes and symptoms) and within a predesignated radius around active sites.
Interest
- Patients searching or engaging (e.g., likes, shares, comments, etc.) with diabetes-indication related content and symptoms are shown study advertisements.
Database
- We email our large database of over 1.3 million registered users based on their location and indication. By continuously analyzing the (anonymized) behavior of those successfully enrolled, we can understand and reach similar people.
Services & Solutions
Addressing patient diversity in migraine trials
Historically, minority and marginalized populations are underrepresented in clinical trials – despite evidence that these populations may be at increased risk of certain health conditions.
While it is generally known that migraine is more common in women (up to three times more common), recent studies show that this indication may occur with different frequency in different ethnic groups. For example, the prevalence is significantly higher in Caucasians (20.4%) than in Africans (16.2%) or Asians (9.2%), while a similar pattern is observed in men (8.6%, 7.2% and 4.2%).
As our Migraine whitepaper highlights, recent surveys show how Migraine patients with Turkish-background in Germany “do not seek medical care because of lack of awareness”. More so, younger migraine patients have generally less awareness of the their condition, let alone of treatment options or the importance of clinical research.
A commonly cited challenge for migraine clinical trials is a unbalanced gender enrolment clinical trials. Despite that migraine is at least three times as common in women as it is in men, the International Headache Society Clinical Trials have highlighted that in clinical trials there are often fewer male participants then is required. This can be linked to recruitment practices relying on referrals from doctor offices where women have a higher consultation rate for migraine than men.
As we argued in our academic whitepaper “Achieving Diversity in Clinical Trials”, digital patient recruitment offers a fast and efficient way to broaden the geographic scope to target eligible Migraine patients. Our 10+ years of experience recruiting for Migraine studies allows us to select outreach tactics that make for a representative and diverse study population.
Case study
Our diabetes case studies
Learn how we’ve supported sponsors with their patient recruitment for diabetes studies, across the globe, resulting in more engagement, more referrals, at less than the budgeted costs:
- Over 2,100 ClinLife referrals
- Successful targeting of patient subpopulation
- Our campaign generated >1.6 million ClinLife website visits
- RWE-driven strategy from 100k patients in 46 countries
Please note that we will not share your data with any 3rd parties, data submitted will be used in accordance with our data privacy policy.
